Saturday, October 22, 2011

The Madness of King George: A Misunderstood King

George III in his coronation robes.
His Royal Highness the Prince of Wales, George William Frederick (June 4, 1738-January 29, 1820) became King of the Great Britain and Ireland as George III on October 25, 1760 when his grandfather, King George II, died after passing out unceremoniously and unfortunately while using the toilet early in the morning. The former king had lived to the age of 77, longer than any recorded English monarch up to that point. The new monarch was only 22 years old when he took the title King and 23 at his coronation but he had extensive schooling from his tutors and, unlike the previous two British kings of the House of Hanover, spoke English as a first language (instead of German), never visited the Electorate/Kingdom of Hanover in Germany which he became king of eventually, and was wholeheartedly British.

However, the king had a dreadful problem. He suffered from several episodes of serious physical and mental illness throughout his life that were well-documented thanks to his high station. It is widely believed now that the king had a hematological disease called acute intermittent porphyria (AIP). First of all, unlike other royal afflictions such as mandibular prognathism in the Hapsburg family (more on that another day), porphyria is not the result of marriage between close relatives (inbreeding). Rather, AIP is a hereditary disease that is autosomal dominant, meaning that someone affected by it has a 50% chance of passing it on to each of his children. The disease can lay dormant for one's whole life and often needs a trigger (like a change in medicine, stress, diet, etc.) to bring out an acute attack, explaining why neither of George III's parents had notable symptoms. One of King George's descendants, Prince William of Gloucester (December 18, 1941–August 28, 1972) was diagnosed with variegate porphyria (VP), a similar porphyria with hepatic and cutaneous symptoms and autosomal dominant inheritance pattern.

Prince William suffered from porphyria too.
An attack of acute intermittent porphyria is manifested by a wide range of symptoms. The actual cause of the attack is the absence of an enzyme, porphobilinogen deaminase, that converts a chemical called a porphyrin into heme, a component of hemoglobin, the iron-based chemical in red blood cells that carries oxygen around the body. Porphyrins are toxic to the body in high doses and attacks occur when stress, diet, or something else causes the body to not be able to filter the excess porphyrins. Pain is severe and most often located in the abdomen and the hands and feet (peripheral neuropathy). Often pain needs to be treated with IV morphine or other equally strong narcotics. Insomnia is common. Nausea, vomiting, constipation, and diarrhea all can occur. Muscle weakness, seizures, headaches, forgetfulness and confusion are often the neurological symptoms. The heart races and tachycardia (high heart rate) and hypertension (high blood pressure) are not uncommon even when an attack is not occurring. Psychiatric problems can occur and can sometimes be the only manifestation of the disease. Often individuals afflicted with porphyria are simply depressed and have anxiety issues but in more severe attacks serious cases of paranoia and psychosis can occur. Finally, AIP is often marked by a distinct purple color in urine and stool during an attack, hence it's name which is related to the Greek word for "purple" (a book about George III's porphyria is titled Purple Secret). There can often be other symptoms. There is no cure and the treatment is usually just of symptoms. One medicine, called Panhematin is available to treat the cause of porphyria but requires an IV and is difficult to find as most hospital pharmacies do not carry it and only one company in the United States makes it. Other than Panhematin, IV glucose (sugar) is used sometimes because carbohydrates are known to help stop attacks. Opiates are used for pain, phenothiazines are used for nausea, and benzodiazepines are, very cautiously, used for seizures. Barbiturates and many other drugs are known to be porphyrogenic, i.e., trigger attacks of AIP. Arsenic, now known to be poisonous in any individual, is one of the most dangerous substances to ingest for someone with any porphyria. In 2003, samples of George III's hair and wigs were analyzed and arsenic was found in them, most likely a medication given to him for his illness that in a cruel twist of fate actually made his condition worse.

George III is often remembered as "Mad King George." In fact, the playwright Alan Bennett wrote a play called The Madness of George III in 1991 which was adapted as a movie, The Madness of King George in 1994.The play and movie focus on the unfortunate king's mental illness rather than his successful military campaigns during the Napoleonic Wars and his warm welcome of the United States to the international scene after the defeat of Britain in the American War of Independence. Rather, he is also remember often as the king who lost the American colonies (the United States was founded during his reign). Some bloggers have even asserted that if it weren't for porphyria, the United States wouldn't exist and we'd all be drinking tea and singing God Save the Queen today (presumably on the assumption that the king was crazy due to the disease and mishandled the colonies and the war).

 However, a lot of scholarship now has a more positive outlook on George III's reign, the longest in British history up to that point. Let us try to look at George III like unbiased historians rather than Americans who are most familiar with the king as the despot who ruled with "absolute tyranny" to whom the Declaration of Independence was addressed. George III was actually quick to respect the United States as a new country, welcoming John Adams as the de facto ambassador from the US (his title was Minister Plenipotentiary to the Court of St. James's). John Adams did not stay at the court for long, however. According to US Department of State Historians, John Adams "became so frustrated with the cool reception [from George III's court] that he closed the legation in 1788 and the post remained vacant for four years."


It seems from his dealings with the infant United States that King George III was in fact a rather honorable man. He also enjoyed some simple pleasures. Sometimes remembered as "Farmer George," the King had somewhat of a green thumb, liked to tend to his garden, and was very interested in agriculture in general. He loved spending time at what is now called the Royal Botanic Gardens in Kew. He was also a skilled equestrian.

George III in 1820, the year he died.
However, with regards to the king's disease acute intermittent porphyria, George III suffered attacks often. His most notable episodes occurred in the early 1780s, 1804, and 1810. He was immensely popular in 1810 but his deteriorating condition caused parliament to pass the Regency Act of 1811, officially titled the "Care of King During his Illness, etc. Act of 1811," of which this year is the 200th anniversary. The law passed control of the monarchy to his son, the future King George IV.

Suffering all the typical symptoms of AIP, the king also was almost totally blind and in chronic pain. It is rumored that he would speak for hours on end about nothing and sometimes would wander around nearly or entirely naked. He never learned of the death of his son Prince Edward, the Duke of Kent, Queen Victoria's father. He never knew that he was proclaimed King of Hanover and the Electorate of Hanover was elevated to a Kingdom. He died with his favorite son, Prince Frederick, the Duke of York, by his side on January 29, 1820 around 8:30 PM, in incredible pain, grief-stricken over the death of his youngest and favorite daughter Princess Amelia, and most likely conscious but psychotic until the bitter end. If ever there was a "tyrant" that one can feel sympathy for, it is the misunderstood King George III.

As a side note, I have a particularly strong interest in George III and porphyria. My grandmother suffered from acute intermittent porphyria and it is likely that my mother, my sister, and I all have inherited it. For more information on porphyria, or to help promote awareness of the rare but serious hematological disease, check out the American Porphyria Foundation and learn about the different porphyrias to become more aware. Here's an interesting tidbit to pique your interest: porphyria is sometimes cited as a cause or contributor to vampire and werewolf myths.

23 comments:

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  2. Excellent article! I picked up a copy of J.B. Priestley's The Prince of Pleasure and his Regency and after reading the author's rather abbreviated comments connecting George III's porphyria to the latter's apparent madness, went in search of further explanation and found you. Thank you so much.

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  18. I never believed in Love Spells or Magics until I met this special spell caster when i went to Africa to Execute some business..He is really powerful..My husband divorce me with no reason for almost 4 years and i tried all i could to have him back cos i really love him so much but all my effort did not work out.. we met at our early age at the college and we both have feelings for each other and we got married happily for 5 years with no kid and he woke up one morning and he told me he’s going on a divorce..i thought it was a joke and when he came back from work he tender to me a divorce letter and he packed all his loads from my house..i ran mad and i tried all i could to have him back but all did not work out..i was lonely for almost 4 years So when i told the spell caster what happened he said he will help me and he asked for his full name and his picture..i gave him that..At first i was skeptical but i gave it a try cos have tried so many spell casters and there is no solution…so when he finished with the readings,he got back to me that he’is with a woman and that woman is the reason why he left me The spell caster said he will help me with a spell that will surely bring him back.but i never believe all this…he told me i will see a positive result within 5 days..5 days later,he called me himself and came to me apologizing and he told me he will come back to me..I cant believe this,it was like a dream cos i never believe this will work out after trying many spell casters and there is no solution..The spell caster is so powerful and after that we are now happy been together again and with lovely kid..This spell caster has really changed my life and i will forever thankful to him..he has helped many of my friends too with similar problem too and they are happy and thankful to him..This man is indeed the most powerful spell caster I have ever experienced in life..Am Posting this to the Forum in case there is anyone who has similar problem and still looking for a way out..you can reach him here: dronobumerespellhome@gmail.com CONTACT THIS POWERFUL SPELL CASTER TODAY VIA EMAIL:dronobumerespellhome@gmail.com

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  19. i want to say a big thank to Dr Ererdiawa Okoh and also let the world know how i was cure of HERPES and CANCER by this Great Doc, who make me believe in the power of Roots and Herbal, for the past 10 years i was living in hell,going true pain with this dead disease HERPES and CANCER,i have spent a lot and take a lot of drugs like. Paclitaxel, Tamoxifen, Vinblastine, Vincristine, Methotrexate, Streptozocin, Procarbazine, Mitomycin acyclovir, famciclovir, and valacyclovir nor of this work for good, it come to time i just want to take my life cause life was mainingless to me and all i have worked for was useless to me, my family all lift me on this, so on this faithful morning march, 23th, 2017, i was going true same massages of hope that with "God all things are possible, there i same a comment by Kate Mark, who said a lot about Dr EREDIAWA, on how she was cure of herpes STD, for long time by this great Doc, i feel so much joy but this time i was ready to do anything to see i get cure of this Virus, but first i email Kate Mark and she responded and told me more about, Doc Erediawa, that him has cure to my Cancer and Herpes,that i should contract him, so i email him on his mail address:drerediawaherbs@gmail.com i told he all i have been passing true all this years,him gave me his word and told me that i should believe in the power of ROOTS and HERBS, which i did, he told me all i need to do and my information,which i gave he,him told me he will have to prepare two types of herbal medication for me to apply for five weeks, also make me to understand during intake of this herbal medication what i need to avid,Sex,smoking and Alcoholic drink, which i did, to my surprise and still wondering if this is a dream i was cure of Herpes and Cancer just in five weeks,what i have spent a lot for and almost took my life. What more can i say or do but to let the world know about this Great Doc Ererdiaw Okoh and to say thanks Doc. i know will all have one or two DISEASE don,t not give up your cure is here, just email him drerediwaherbs@gmail.com or whatsapp him +2348159412586

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  20. When life give you reasons to be sad say No and Make the world know that you have more than a thousand reasons to smile. I almost gave up on my quest of finding a permanent cure to this nasty virus called HIV. I never thought i would be HIV negative again after been diagnosed in 2013, i have tried everything possible in life from one doctor to another, one hospital to another, series of tests, different kinds of medication, i had already lost hope until i melt silver sandy Philippe who kindly told me about DR.ODUDU who do cure difference virus by the preparation of herbs and roots. i searched about the DR online which leads me to a difference testimonies on about the great herbal DR. I so decided to made up my mind to give him a try, i contacted his email that was given in the post and I followed him with all amount of seriousness and i did all he instructed me. To my greatest surprise, the disease that seem incurable disappear within 20 days of using his remedy. I am writing this here in order to put you in the know that there is a cure for this virus. it time to stop believing in the medical doctors who do says to us there is known cure for Cancer Hiv and many more virus. i just want you known that if you are going through any health challenge, contact this man and follow his instruction diligently and have a disease free life. his email is (dr.oduduherbalhome@gmail.com) a living dog is far better than a dead lion and a good health worth more than wealth famous, so please get back your health by getting in touch with DR.ODUDU kindly get him contacted calling phone contact and his Whats App contact is +2348101571054 thanks. https://web.facebook.com/DR.ODUDUHERBALHOME/?fref=ts

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